A diploid human genome contains approximately six billion nucleotides. This enormous amount of genetic information can be replicated with great accuracy in only a few hours. However, because DNA strands are oriented antiparallel while DNA polymerization only occurs in the 5′ → 3′ direction, semi‐conservative replication of double‐stranded DNA is an asymmetric process, i.e., there is a leading and a lagging strand. This provides a considerable opportunity for non‐random error rates, because the architecture of the two strands as well as (...) the DNA polymerases that replicate them may be different. In addition, the proteins that start or finish chains may well be different from those that perform the bulk of chain elongation. Furthermore, while replication fidelity depends on the absolute and relative concentrations of the four deoxyribonucleotide precursors, these are not equal in vivo, not constant throughout the cell cycle, and not necessarily equivalent in all cell types. Finally, the fidelity of DNA synthesis is sequence‐dependent and the eukaryotic nuclear genome is a heterogeneous substrate. It contains repetitive and non‐repetitive sequences and can actually be considered as two subgenomes that differ in nucleotide composition and gene content and that replicate at different times. The effects that each of these asymmetries may have on error rates during replication of the eukaryotic genome are discussed. (shrink)

The Genesis of God: A Theological Genealogy. By Thomas J.J. Altizer. Louisville: Westminster/John Knox Press, 1993. pp.200.

The device of setting forth an argument in the form of a postulate set, while not unknown to jurisprudence, is nevertheless sufficiently novel to justify a brief account of the process. At one time human thought took axioms and postulates for avowals of unalterable truth, but the nineteenth century made common the practice of speculating with alternative presuppositional systems, so that deeper insight into the nature of this scientific device revealed it as merely a method among many for clarifying and (...) fecundating thought. (shrink)

Abstract Kaldor, one of the leading figures of the post?war ?Cambridge School?, has produced a large volume of methodological writings since the mid?1960s, which we will argue represents one of the major critiques of orthodox equilibrium economic theory produced this century. While Kaldor's position represents a fundamental and radical rejection of the methodological basis of equilibrium economics, he did not provide a systematically formulated alternative methodology for economics. Recent attempts at providing such a reconstruction has argued that scientific realism provides (...) the most convincing philosophical interpretation of Kaldor's methodological contributions. In this paper we will argue that van Fraassen's constructive empiricism represent a more compelling alternative methodological framework to realism for systematizing Kaldor's important contributions. In particular it will be argued that this constructive empiricist reading of Kaldor has the capacity to critically undermine the methodological basis of orthodox equilibrium economics. In addition we explore the potential of this alternative framework to provide a novel and challenging reconstruction of economic methodology. (shrink)

The dissertation explores the philosophical, literary, and stylistic similarities between the twentieth century American writer Sherwood Anderson and the nineteenth century Danish philosopher Soren Kierkegaard. These similarities suggest that the Ohio writer's work and aesthetic were deeply influenced by the Danish thinker, and the connection between them lies in the immigrant rural religious communities of the American Middle West. Ultimately, these interrelations reveal a "religious-aesthetic" unique to the entire range of Midwestern literature of the late-nineteenth and early-twentieth centuries, and they (...) also reveal a politics and an aesthetic of Midwestern art available yet today. (shrink)

Since the late 1980s, obesity in America has been a looming public health concern. Recently, medical researchers found that, for the 2011‐12 period, 35.3 percent of U.S. adults (aged 20 or older), 20.5 percent of teenagers (ages 12‐19), 17.7 percent of children (ages 6‐11), and 8.4 percent of young children (ages 2‐5) have obesity, and 6.3 percent of U.S. adults having severe obesity. In a recent working paper by Karnani, McFerran, and Mukhopadhyay (2015), these management scholars argue that obesity represents (...) a market failure. In their study, Karnani et al. evaluate the effectiveness of corporate social responsibility, industry self‐regulation, social activism, and government regulation as to its effectiveness on consumer behavior and reducing obesity. Karnani et al. are advocates of “reasonable” government intervention, i.e., tax/subsidies, market regulation, and education, to address the public health issue of obesity. However, evidence shows that reasonable government intervention is also vulnerable to government failure and potential public health risk. Recommended is a mix of institutional activities found in corporate social responsibility, industry self‐regulation, social activism, and government intervention, all of which should provide the direction needed to continue this public health trend away from America’s epidemic levels of obesity. (shrink)

Charles Peirce had a flair for asking fruitful questions and for proposing answers that did not block the way of inquiry. Typical examples occur in his philosophy of science where he raises issues that are still very much alive. They include such items as the nature and conditions of scientific progress, the grounds of human success in formulating theories, the completability of scientific knowledge, and the limits imposed by the economy of research. Because these are living issues, Peirce's ideas about (...) them invite examination as if he were our philosophical contemporary. Nicholas Rescher so examines them in his compact, timely book. His treatment is sympathetic but by no means uncritical, as might have been expected in view of the similarities and differences between his own position of methodological pragmatism and the pragmaticism of Peirce. The ensuing discussion thus seems to me worth looking at in a bit of detail. (shrink)

To be a player in the international standards-setting arena of network industries, such as those dealing with information technology, reaching an early domestic consensus for a critical interoperable technology design is often essential. While in most cases efficient outcomes emerge through the market-driven, U.S. technology standards system, there have been situations where a timely consensus has failed to be attained with negative consequences for the international competitiveness of the U.S. economy (e.g., second generation of cellular telephony). An anticipatory policy approach, (...) based on a standards competition which takes into consideration antitrust and intellectual property rights, is proposed as a solution. (shrink)

The Global Economic Ethic Manifesto is a credo embodying a set of basic transcultural values aimed at encouraging ethical dealings by business enterprises. However, through analysis of documents and expert interviews, study findings reveal that there has been little adoption and/or implementation of the Ethic Manifesto since its celebrated United Nations launching in 2009. Only sixty-three signatories have signed on, consisting of a majority of individuals, and the remaining twenty-seven are primarily affiliated with European business enterprises. Our study recommendations include (...) tighter integration of the Ethic Manifesto with the Global Compact; an organizational commitment, i.e., by the CEO and board of directors, to the Ethic Manifesto; a broad-based reporting requirement on general progress in meeting the Ethic Manifesto’s principles; and business enterprise use of a logo indicating conformance with the principles of the Ethic Manifesto to stakeholders, all of which could improve business enterprise participation in this civil society initiative. (shrink)

Among the oldest extant medical ethics, the Hippocratic Oath prohibits the giving of a deadly drug, regarding this act as an egregious violation of a medical ethic that is exclusively therapeutic. Proportionate palliative sedation involves the administration of a deadly drug. Hence it seems to violate the venerable Hippocratic promise associated with the dawn of Western medicine not to give a deadly drug. Relying on distinctions commonly employed in the analysis and evaluation of human actions, this article distinguishes physician-assisted suicide (...) and euthanasia, as acts that necessarily violate the prohibition against giving a deadly drug, from proportionate palliative sedation, as an act that does not. (shrink)

The chair of the ethics committee of a major medical center agonized over how he, as a physician, and his organization should deal with Initiative 119, which, if passed, would legalize physician involvement in active, voluntary euthanasia in Washington State. In the end, he said, he could not vote for aid-in-dying because, “However much I want to reduce suffering, I myself just couldn’t do it to one of my patients.” He spoke of a personal distaste for the potential act, of (...) a profound desire not to have to do it. It was not an ethical argument, but an honest and compelling expression of feelings.Why can’t this sincere man do it, even for patients who request such aid? In a 1991 poll, taken in Washington State prior to the vote on Initiative 119, 49 percent of the physicians surveyed supported the initiative, but 75 percent did not want to participate in aid-in-dying. (shrink)

Since the onset of the latest United States (U.S.) recession (beginning in December 2007), the U.S. economy has been posting high unemployment levels consistently exceeding 8 percent. Of specific interest, the U.S. Department of Labor, Bureau of Labor Statistics (BLS), reports on a specific subset of the U.S. unemployed: the long‐term unemployed, defined as those who are unemployed for 27 weeks and over. Since December 2009, the share of the long‐term unemployed of the total U.S. unemployed has exceeded 40 percent (...) (through April 2012), the highest level since 1948 when data was first collected. A phenomenon of this recession is an alleged public bias by American private sector employers against hiring the long‐term unemployed, or even simply those unemployed. While the authors support the removal of discrimination against the unemployed in job advertisements, they cannot support the larger notion of including those who are unemployed as a protected class of employees. Becoming or being unemployed is a state that one can change, and based on the lack of research on how widespread this discrimination is (beyond anecdotal stories or limited research surveys), they believe that extending protection under equal employment opportunity legislation would be overreaching and inappropriate at this time. (shrink)

This essay consists of (a) an exploration of the relation between Aquinas and Heidegger as this is discussed in the work of John Caputo, and (b) an attempt, in the light of what is learned from the previous discussion, to rethink the essence of Thomistic metaphysics in a way that is both faithful to the spirit of Thomism, remaining attentive to its mystical source, and alive to the mystery of Being in a Heideggerian sense. In this way the argumental structure (...) central to that metaphysics is treated as a Wittgensteinian ladder that we can kick away, that is, which auto-deconstructs, thereby placing us before unlimited, unqualified existence, the Difference between existence and nothingness. The essay ends with a suggestion for a transformation of Heidegger’s Denken along lines suggested by this rethinking of Thomism. A reply by John Caputo follows the essay. (shrink)

Following Amartya Sen’s insistence to expand the framework of rational choice theory by taking into account ‘non-utility information,’ economists, political scientists and philosophers have recently concentrated their efforts in analysing the issues related to rights, freedom, diversity intentions and equality. Thomas Boylan and Ruvin Gekker have gathered essays that reflect this trend. The particular themes addressed in this volume include: the measurement of diversity and freedom, formal analysis of individual rights and intentions, judgment aggregation under constraints and strategic manipulation (...) in fuzzy environments. Some papers in the volume also deal with philosophical aspects of normative social choice. (shrink)

SINCE the work of Gottlob Frege the question of sense and meaning has been regarded by logicians as perhaps the most important problem of philosophy. We may gain some idea of how important this question is to the modern logician from the words of one of the leading analytical philosophers, Gilbert Ryle.